Synlett · 2003 · 38 citations · 0 references
Natural SciencesChemistryOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisOrganic SynthesisAsymmetric Heterocycle SynthesisAza-diels-alder ReactionAzone DerivativesHeterocycle FunctionalizationLewis Acid CatalysisLewis Acidity
Reaction of 4-trimethylsilyl-3-butenyl-1-amines with aldehydes under mild Lewis acid conditions gives substituted tetrahydropyridines in excellent yields and with excellent trans diastereoselectivity.