A Stereoselective Three-Component Reaction: KAl(SO₄)₂·12H₂O, an Efficient and Reusable Catalyst for the One-Pot Synthesis of <i>cis-</i>Isoquinolonic Acids

Abstract

KAl(SO(4))(2).12H(2)O is found to catalyze efficiently the stereoselective one-pot three-component cyclocondensation of homophthalic anhydride, aldehydes, and amines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.