A Concise Account of Recent S_N2′ Grignard Coupling Reactions in Organic Synthesis

Abstract

Over the past few decades studies on controlling the chemo-, regio- and stereoselectivities of allylic substitution reactions have been well documented in the literature and the SN2′ Grignard coupling reaction has emerged as a very powerful tool in selective carbon-carbon bond formation. This review focuses on all the recent synthetic developments in this special class of reactions.