Stereoselective Synthesis of 1,2-Aminoalcohols by [2,3]-Wittig Rearrangements

Abstract

[2,3]-Wittig rearrangements of (E)-3-aza-allylic alcohol derivatives can provide access to functionalized 1,2-aminoalcohols with high syn or anti diastereoselectivity depending on the anionic stabilizing group (amide or alkyne).