New efficient approach for the synthesis of 2‐alkyl(aryl) substituted 4<i>H</i>‐pyrido[1,2‐<i>a</i>]pyrimidin‐4‐ones

Abstract

Abstract magnified image A new, efficient and easy route for the preparation of a series of 2‐alkyl(aryl) substituted 4‐oxo‐4 H ‐pyrido‐[1,2‐ a ]pyrimidines, where alkyl = CH 3 ; aryl = C 6 H 5 , 4‐FC 6 H 4 , 4‐ClC 6 H 4 , 4‐BrC 6 H 4 , 4‐CH 3 C 6 H 4 , 4‐OCH 3 C 6 H 4 , 4‐NO 2 C 6 H 4 in 45–80 % yield from the reaction of β‐alkoxyvinyl trichloromethyl ketones with 2‐aminopyridine under mild conditions, is then reported.