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<i>N</i>-Bromosuccinimide as a Regioselective Nuclear Monobrominating Reagent for Phenols and Naphthols
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1997
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EngineeringBiochemistrySubstituted PhenolsNatural SciencesNuclear Bromination ProductsCarbon DisulfideOrganic ChemistryChemistryPharmacologyDerivative (Chemistry)Synthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
A wide range of substituted phenols and naphthols were regioselectively monobrominated with N-bromosuccinimide, at para position in acetonitrile and at ortho position in carbon disulfide, under mild conditions in good yields. Methylphenols afforded only nuclear bromination products.