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A new synthesis of (.+-.)-lysergic acid.
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1986
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Medicinal ChemistryBioorganic ChemistryEngineeringBiochemistryAldol CondensationNatural SciencesAldehyde DehydrogenaseOrganic ChemistryNew SynthesisKey ReactionStereoselective SynthesisSimple SynthesisPharmacologySynthetic ChemistryBiomolecular EngineeringNatural Product Synthesis
A new and simple synthesis of (±)-lysergic acid from the aldehyde (5___-)is described involving aldol condensation with 3___- in the presence of LDA as a key reaction.