Design of Antineoplastic Agents on the Basis of the "2-Phenylnaphthalene-Type" Structural Pattern. I. Synthesis of Substituted 3-Phenylquinazolones, Benzoxazolo[2,3-b]quinazolones and Benzothiazolo[2,3-b]quinazolones

Abstract

A number of substituted 3-phenylquinazolin-4-ones, 12H-benzoxazolo-[2,3-b]quinazolin-12-ones and 12H-benzothiazolo[2,3-b]quinazolin-12-ones were designed and synthesized on the basis of a «2-phenylnaphthalene-type» structural pattern hypothesis. The postulated pattern, which was uncovered among a substantial number of compounds of both natural and synthetic origins, was noted to be associated with compounds possessing a variety of biological properties which include the antineoplastic activity. Several compounds designed for the present study were found to exhibit potent cytotoxicity against the growth of human promyelocytic leukemia (HL-60) cells