Organic Letters · 2005 · 39 citations · 24 references
PharmacyBotanyPlant SciencesNatural Product BiosynthesisPlant BiochemistryStructure-activity RelationshipsAlkaloid BiosynthesisHeterocyclic ChemistryMedicinal PlantsPlant Natural Product BiosynthesisAlkaloid ProfilesAlkaloid Skeleton FormationPlant AlkaloidsSimulation AnalysisSimulation-based Analysis
[structure: see text] Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis.
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