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Two flavones from Scutellaria baicalensis Georgi and their binding affinities to the benzodiazepine site of the GABAA receptor complex.
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2002
Year
New Flavone 6,2'-Dihydroxy-5,7,8,6'-tetramethoxyflavoneMolecular PharmacologyMedicinal ChemistryScutellaria Baicalensis GeorgiPhytopharmacologyPhytochemicalBiochemistryMechanism Of ActionNeuropharmacologyBenzodiazepine SitePharmacologyRadioligand ReceptorGabaa Receptor ComplexNatural SciencesHerb-drug InteractionPhytochemistryMedicineDrug DiscoveryDrug Analysis
A new flavone 6,2'-dihydroxy-5,7,8,6'-tetramethoxyflavone (1) together with one known flavone 5,7,2'-trihydroxy-6,8-dimethoxyflavone (2) were isolated from the roots of Scutellaria baicalensis Georgi. Their structures were elucidated on the basis of spectral evidence and their affinities for the benzodiazepine (BDZ) site of the GABAA receptor complex were evaluated with a radioligand receptor binding assay.