Regioselective Hydroformylation of Sulfonamides using a Scaffolding Ligand

Abstract

A highly regioselective hydroformylation of allylic sulfonamides has been developed by employing a catalytic directing group. The reaction tolerates a wide range of electronically and sterically modified olefins, and only 10% of the scaffolding ligand is required to effectively control the regioselectivity.