Enantioselective Copper-Catalyzed O-H Insertion of α-Diazo Phosphonates

Abstract

A copper-catalyzed asymmetric O-H insertion of α-di­azo phosphonates with alcohols by using chiral spiro bisoxazoline ligands was developed. The insertion reaction exhibited good yields (up to 89%) with high enantioselectivities (up to 98% ee) and provided an efficient approach for synthesis of enantiomerically enriched α-alkoxy and hydroxy phosphonate derivatives starting from readily available materials.