Concepedia

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Anthony Virtue, Sam J. McCright, Jasmine M. Wright, Monica T. Jimenez, Walter K. Mowel, Jonathan J. Kotzin, Leonel Joannas, Megha Basavappa, Sean P. Spencer, Megan L. Clark,

Science Translational Medicine · 2019 · 323 citations · 46 references

DOIFull text

Open access

Concepts

Abstract

Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.

References

46

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.6K citations · Full text

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Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.3K citations · Full text

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The gut microbiota as an environmental factor that regulates fat storage

Fredrik Bäckhed, Hao Ding, Ting Wang et al. · Proceedings of the National Academy of Sciences · 2004 · 6.2K citations · Full text

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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Zeneng Wang, Elizabeth Klipfell, Brian J. Bennett et al. · Nature · 2011 · 5.6K citations

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Carey N. Lumeng, Jennifer L. Bodzin, Alan R. Saltiel · Journal of Clinical Investigation · 2007 · 4.6K citations · Full text

, , +17