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A Convenient Method for the Synthesis of <b><i>N</i></b>-Vinyl Derivatives of Nucleobases
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2002
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Vinyl AcetateEngineeringBiochemistryNatural SciencesConvenient MethodMolecular BiologyOrganic ChemistryEnormous FlexibilityClick ChemistryChemistryNatural Product SynthesisDerivative (Chemistry)Synthetic ChemistryBiomolecular EngineeringTrimethylsilyl Trifluoromethanesulfonate
Trimethylsilyl trifluoromethanesulfonate (TMSOTf) reveals, one more time, its enormous flexibility as Lewis acid catalyst, transforming the well known, but drastic, exchange of the acetyl group of vinyl acetate with pyrimidine and purine derivatives in a very gentle and quick method to obtain a whole set of vinyl nucleobases.