Concepedia

Synthesis and Reactivity of <i>N</i>-Acyl-5- (1-hydroxyalkyl)-2,3-dihydro-4-pyridones

Daniel L. Comins, Anne‐Cecile Hiebel, Shenlin Huang

Organic Letters · 2001 · 24 citations · 10 references

DOI

Concepts

Abstract

[structure: see text]. The Nozaki-Hiyama-Kishi reaction was used to prepare the 5-(1-hydroxyalkyl)-2,3-dihydro-4-pyridones 3. Reduction, oxidation, and substitution reactions of 3 were examined.

References

10

Asymmetric Synthesis of 2-Alkyl(Aryl)-2,3-dihydro-4-pyridones by Addition of Grignard Reagents to Chiral 1-Acyl-4-methoxypyridinium Salts

Daniel L. Comins, Sajan P. Joseph, R. Richard Goehring · Journal of the American Chemical Society · 1994 · 215 citations

, , +10

Total Synthesis of Pinnatoxin A

John A. McCauley, Kazuo Nagasawa, Peter A. Lander et al. · Journal of the American Chemical Society · 1998 · 171 citations

, , +6

Asymmetric synthesis and synthetic utility of 2,3‐dihydro‐4‐pyridones

Daniel L. Comins · Journal of Heterocyclic Chemistry · 1999 · 89 citations

, , +13

Titanium(IV) Chloride and the Amine-Promoted Baylis−Hillman Reaction

Min Shi, Jian‐Kang Jiang, Yanshu Feng · Organic Letters · 2000 · 86 citations

, , +8

Addition of Metallo Enolates to Chiral 1-Acylpyridinium Salts:  Total Synthesis of (+)-Cannabisativine

Jeffrey T. Kuethe, Daniel L. Comins · Organic Letters · 2000 · 62 citations

, , +8