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A Novel Efficient Four- and Five-Component, One-Pot Synthesis of 4-Semicarbazonoalkyl-2-Naphthols
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2008
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Room TemperatureChemical EngineeringCross-coupling ReactionEngineeringEfficient Catalyst SystemNatural SciencesSemicarbazide HydrochlorideDiversity-oriented SynthesisOne-pot SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySynthesis MethodAsymmetric CatalysisSynthetic ChemistryBiomolecular Engineering
One-pot, multicomponent coupling reaction of two or three molecules of aldehydes with 2-naphthols and semicarbazide hydrochloride is described for the preparation of 4-semicarbazonoalkyl-2-naphthols using PTSA/NaOAc as an efficient catalyst system in THF at room temperature or solvent-free conditions at elevated temperature.