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Stereoselective Nickel and Manganese Catalyzed Cyclizations of 5-Haloketones
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1998
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HalogenationEngineeringHeterocyclicHigh StereoselectivityStereoselective NickelOrganic ChemistrySubstituted CyclopentanolsOrganometallic CatalysisCatalysisVarious 5-IodoketonesChemistryPharmacologyEnantioselective Synthesis
The treatment of various 5-iodoketones or 5-bromoketones with Et2Zn in the presence of either Ni(acac)2 (5 mol %) or MnBr2/CuCl (5 mol %) produces functionalized substituted cyclopentanols bearing in some cases contiguous quaternary centers with high stereoselectivity.