Air-Stable Phosphine Sulfide Ligand Precursors for Nickel-Catalyzed Cross-Coupling Reactions of Unactivated Aryl Chlorides with Aryl Grignard Reagents

Abstract

The air-stable phosphine sulfide [( t Bu) 2 P(S)H] serves as a ligand precursor for the efficient nickel-catalyzed cross-coupling reactions of a variety of unactivated aryl chlorides with aryl Grignard reagents (Kumada−Tamao−Corriu reaction) at room temperature to yield the corresponding biaryls with isolated product yields ranging from 79 to 97%.