Concepedia

A Novel, One-Pot, Three-Component Synthesis of 1,2,4-Oxadiazoles under Microwave Irradiation and Solvent-Free Conditions

Mehdi Adib, Mohammad Mahdavi, Niusha Mahmoodi, Hooshang Pirelahi, Hamid Reza Bijanzadeh

Synlett · 2006 · 35 citations · 0 references

Concepts

Combinatorial ChemistryChemical EngineeringEngineeringNatural SciencesDiversity-oriented Synthesis3,5-Disubstituted 1,2,4-OxadiazolesThree-component SynthesisOrganic ChemistrySolvent-free ConditionsMicrowave IrradiationCatalysisMicrowave IrradiationChemistryHeterocycle ChemistrySynthesis MethodPharmacologyMicrowave SynthesisSynthetic Chemistry

Abstract

A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum’s acids under microwave irradiation and solvent-free conditions in good to excellent yields.