Synthesis · 2008 · 12 citations · 0 references
Cross-coupling ReactionEngineeringFacile SynthesisBaylis-hillman AdductsOrganic Chemistry1,5-Diene DerivativesOrganometallic CatalysisChemistryHigh SelectivityAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringMild Reaction Conditions
Morita-Baylis-Hillman adducts undergo smooth allylic nucleophilic substitution (SN2′) with allyltrimethylsilane in the presence of BF3·OEt2 under mild reaction conditions to afford 1,5-diene derivatives in good yields with high selectivity.