Synlett · 2010 · 32 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryGreen ChemistrySynthetic Medicinal ChemistryAddition ReactionsMicrowave-assisted SynthesisSolvent-free SynthesisMicrowave-assisted CatalysisMicrowave-assisted Condensation ReactionsMicrowave-assisted Organic SynthesisMicrowave-assisted Solvent-free SynthesisSolvent-free CatalysisSolvent-free Processing
A high-yielding reaction protocol for the microwave-assisted organocatalytic conjugate addition of diethyl malonate to enones under solvent-free conditions is proposed. The method still permits the use of cheap and commercially available l-proline furnishing very good performance at least in the case of 1-alkyl-3-monosubstituted enones.