A Copper‐Catalyzed C—N Bond Formation Involving sp‐Hybridized Carbons. Direct Entry to Chiral Ynamides via N‐Alkynylation of Amides.

Abstract

A copper-catalyzed new C−N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.