Total Synthesis of Peroxyacarnoates A and D: Metal-Mediated Couplings as a Convergent Approach to Polyunsaturated Peroxides

Abstract

[reaction: see text] The first syntheses of peroxyacarnoates A and D, members of a family of enyne-containing alkoxydioxanes, have been achieved on the basis of chemoselective ozonolysis within a polyunsaturated framework and Pd-mediated cross-couplings of a functionalized 1,2-dioxane.