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One-Pot Esterification and Selective 3α-Acetylation of Cholic and Deoxycholic Acid
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1996
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BiosynthesisSelected EstersEngineeringBiochemistryNatural Product SynthesisOne-pot EsterificationOrganic ChemistrySimple One-pot EsterificationCatalysisStereoselective SynthesisPharmacologySynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringAcetic Acid
A simple one-pot esterification and selective 3α-acetylation of cholic and deoxycholic acid with selected esters of acetic acid (ethyl, propyl and butyl) in the presence of catalytic amount of 4-toluenesulfonic acid and water has been described. The yields of the obtained esters varied in range of 74-95%.