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A Simple and Efficient Procedure for the Synthesis of Amidoalkyl Naphthols by <i>p</i>-TSA in Solution or under Solvent-Free Conditions
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2006
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Room TemperatureChemical EngineeringEngineeringNatural SciencesDiversity-oriented SynthesisSustainable SynthesisOrganic ChemistrySolvent-free ConditionsCatalysisAmidoalkyl NaphtholsChemistrySynthetic ChemistrySynthesis MethodDerivative (Chemistry)Efficient ProcedureDirect ProcedureBiomolecular Engineering
An efficient and direct procedure for the synthesis of amidoalkyl naphthols has been described that employs a three-component condensation reaction in one pot using aromatic aldehydes, β-naphthol and ureas or amides in the presence of p-toluene sulfonic acid in 1,2-dichloroethane at room temperature or under solvent-free conditions at elevated temperature.