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A Facile One-Pot Synthesis of Chiral β-Amino Esters
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2005
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Chiral Ru-clmeobiphep CatalystsChiral β-Amino EstersEngineeringOrganic ChemistryChiral β-Amino EstersCatalysisChemistryAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringAmmonium Acetate
We report a facile one-pot synthesis of chiral β-amino esters via direct reductive amination of β-keto esters with ammonium acetate (NH4OAc) and H2 in the presence of chiral Ru-ClMeOBIPHEP catalysts using 2,2,2-trifluoroethanol (TFE) as a solvent, leading to β-amino esters in high yields with high enantioselectivities (up to 99% ee).