Studies toward the Total Synthesis of Popolohuanone E: Enantioselective Synthesis of 8-<i>O</i>-MethylpopolohuanoneE

Abstract

[structure: see text]. 8-O-methylpopolohuanone E (2) was synthesized in a highly convergent manner starting from the cis-fused decalin derivative accessible from the (-)-Wieland-Miescher ketone analogue. The synthetic method features a biogenetic-type annulation of the phenolic and quinone segments to regioselectively construct the central tricyclic ring system as the key step.