First Total Synthesis of Cassiarin A, a Naturally Occurring Potent Antiplasmodial Alkaloid

Abstract

The first total synthesis of cassiarin A, an antiplasmodial alkaloid isolated from Cassia siamea, was achieved via sequential alkynylation of arenes with Sonogashira coupling and 6- endo-dig-cyclization of phenolic oxygens to the resulting alkynes.