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1,2-Addition of Phenylacetylene to Aldimines Catalyzed by InCl3/CuCl in Water under Barbier Conditions
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2011
Year
Chemical EngineeringEngineeringAlkene MetathesisBimetallic In-cu SystemOrganic ChemistryVarious PropargylaminesOrganometallic CatalysisCatalysisChemistryBarbier ConditionsSimple Barbier-grignard-type ReactionSynthesis MethodAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A new and efficient method for the preparation of various propargylamines has been achieved by the simple Barbier-Grignard-type reaction of phenylacetylene with a variety of aldimines under aqueous conditions, catalyzed by a bimetallic In-Cu system.