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Practical and Efficient Palladium-Promoted Synthesis of Indole Systems Containing Medium- and Large-Ring-Fused Heterocycles
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2006
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EngineeringOrganic ChemistryMicrowave IrradiationChemistryHeterocycle ChemistryLarge-ring-fused HeterocyclesIndolo-benzazonine DerivativesChemical EngineeringOrganometallic CatalysisPalladium-catalyzed Coupling ReactionCross-coupling ReactionDiversity-oriented SynthesisCatalysisSynthesis MethodAsymmetric CatalysisEnantioselective SynthesisEfficient Palladium-promoted SynthesisNatural SciencesSynthetic Chemistry
The synthesis of indolo-benzazepine, indolo-benzazocine and indolo-benzazonine derivatives using a palladium-catalyzed coupling reaction is described. The polycyclic systems were obtained in a few steps directly from commercially available materials. The coupling of substrates containing aryl bromides was improved by microwave irradiation.