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Naturally Occurring δ-Hydroxy-γ-Lactones: Muricatacins and Related Compounds
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2010
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Medicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicineSecondary MetaboliteNatural Product BiosynthesisAnti-cancer AgentStereoselective SynthesisRelated CompoundsCytotoxic ActivityPharmacologyPharmaceutical ChemistryDrug DiscoveryNatural Product Synthesis
In this account we present and critically analyze the different stereoselective synthetic strategies that have been reported in the literature for muricatacins [5-(1-hydroxytridecyl)dihydrofuran-2-ones], naturally occurring δ-hydroxy-γ-lactones related to acetogenins, which display cytotoxic activity towards human tumoral cell lines.