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A Facile Method for the Synthesis of 3-(Aminomethylene)oxindoles from Isatylidene Malononitriles and α-Azido Ketones
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2012
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EngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistrySimple One-pot SynthesisChemistryGood DiastereoselectivityIsatylidene Malononitrilesα-Azido KetonesSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringFacile Method
A simple one-pot synthesis of 3-(aminomethylene)oxindoles was achieved by the reaction of α-azido ketones and isatylidene malononitriles via Michael addition followed by the conversion of azides to amines. All the synthesized 3-(aminomethylene)oxindoles exhibited good diastereoselectivity<i>.</i>