Novel and Efficient Synthesis of 8-Oxoadenine Derivatives

Abstract

A novel synthetic method of 8-oxoadenine derivatives (3 and 4) is reported.This widely applicable synthetic method was realized through the use of 5-amino-4-cyano-2-oxoimidazole derivatives (2) as the key intermediates.A variety of substituents were successfully introduced to the 2-and 9-position of the 8-oxoadenine nucleus.