Regiospecific Synthesis of Unsymmetrical α-Bromoketones

Abstract

Abstract A convenient regiospecific preparation of unsymmetrical α-bromoketones, commencing from Meldrum's acid, has been developed. This procedure allows for preparation of α-bromoketones which are unobtainable in a pure state by other bromination methods and is compatable with introduction of a bromine atom in the presence of unsaturation using low-cost starting materials.