Asymmetric Michael Reaction Involving Chiral Imines/Secondary Enamines: Stereocontrolled Synthesis of 2,2-Disubstituted Tetrahydrothiophen-3-ones

Abstract

[reaction: see text] The asymmetric Michael reaction involving a chiral imine derived from 2-methyltetrahydrothiophenone-3-one and enantiopure (R)-1-phenylethylamine with a variety of electrophilic alkenes furnished 2,2-disubstituted tetrahydrothiophenone-3-ones with good yields and excellent stereoselectivity.