Access to Pyrrolo- and Pyrido[1,2-<i>a</i>]indole Derivatives by Intramolecular Nitrone Cycloadditions. Effect of Steric Factors on the Regioselective Product Formation

Abstract

On starting from N-allyl-substituted 2-indolecarbaldehydes and exploiting the intramolecular nitrone cycloaddition methodology, we synthesized a number of the title fused-ring indole derivatives in racemic as well as enantiopure form.