Hypervalent Iodine Reagents as Powerful Electrophiles

Abstract

Hypervalent iodine reagents have been investigated as very powerful electrophiles in many different reactions. Efficient formation of new carbon–heteroatom bonds as well as carbon–­carbon bonds can be achieved typically under mild reaction conditions with these metal-free reagents. Enantiomerically pure reagents provide the potential for stereoselective reactions and this aspect is highlighted in this account. 1 Introduction 2 Stereoselective Reactions 3 Reactions with Alkenes 3.1 Iodolactonizations 3.2 Oxyaminations of Alkenes 3.3 Aziridinations of Alkenes 4 α-Functionalization of Carbonyl Compounds and Catalysis 5 Rearrangements 6 Arylations 7 Oxidations 8 Summary and Outlook