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Metal-Free Brønsted Acid Catalyzed Transfer Hydrogenation - New Organocatalytic Reduction of Quinolines
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2006
Year
Chemical EngineeringNovel OrganocatalystsEngineeringHydrogen SourceHeteroaromatic CompoundsNatural SciencesDiversity-oriented SynthesisNew Organocatalytic ReductionHantzsch DihydropyridineOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryHeterocycle ChemistryMolecular CatalysisEnantioselective SynthesisCatalytic Synthesis
The first metal-free Brønsted acid catalyzed hydrogenation of quinolines using Hantzsch dihydropyridine as the hydrogen source has been developed. This, so far unprecedented organocatalytic reduction of heteroaromatic compounds provides a variety of differently substituted 1,2,3,4-tetrahydroquinolines in excellent yields under mild reaction conditions using a remarkably low amount of Brønsted acid catalyst.