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One-Step Synthesis of Thioaurones
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2002
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One-step PreparationEngineeringHeterocyclicNatural SciencesAldol-type CondensationDiversity-oriented SynthesisOrganic ChemistryOne-step SynthesisStereoselective SynthesisChemistryHeterocycle ChemistryEnantioselective SynthesisBiomolecular Engineering
A rapid, one-step preparation of 2-(arylmethylidene)-1-benzothiophen-3-ones (thioaurones) using directed α-metallation, ring closure and aldol-type condensation is described. The reaction leads exclusively to the Z-isomer.