Chemistry of Tetrahydroisoquinoline Antitumor Natural Products: Preparation and Antitumor Activity of Analogues of Cribrostatin 4

Abstract

The two-step transformation of saframycin G(9)into saframycin F (1b) and renieramycin O (11) into renieramycin Q ( 2) is described, along with the results of cytotoxicity studies.