Efficient Synthesis of <i>trans</i>-Fused Polycyclic Ethers Including Tetrahydropyrans and Oxepanes Based on SmI₂-Induced Reductive Cyclization

Abstract

An efficient method for the synthesis of trans-fused polycyclic ether ring systems including tetrahydropyrans and oxepanes, i.e., six−seven−six-, six−seven−seven-, and six−seven−seven−six-membered polycyclic ether ring systems, was developed on the basis of SmI2-induced reductive intramolecular cyclization.