Concepedia

A Convenient Synthesis of Primary 2-Hydroxyorganophosphines from Red Phosphorus and Oxiranes

S. N. Arbuzova, L. Brandsma, Nina K. Gusarova, A. H. T. M. van der Kerk, M. C. J. M. van Hooijdonk

Synthesis · 2000 · 13 citations · 0 references

Concepts

Natural SciencesChemistryMedicinal ChemistryInorganic ChemistryOrganic ChemistryOrganometallic ChemistryHeterocyclic ChemistryOrganic SynthesisPhosphide Synthesis

Abstract

A number of 2-hydroxyorganophosphines HOCH(R1)CH(R2)PH2 2 have been obtained in good yields by reaction of oxiranes with sodium monophosphide, generated in situ from red phosphorus, sodium and tert-butyl alcohol in liquid ammonia.