Synthesis of furo[2,3‐<i>b</i>]pyridine

Abstract

Abstract Two routes were employed to synthesize unsubstituted furo[2,3‐ b ]pyridine (IV). The first method started with ethyl 5‐aminofuro[2,3‐ b ] pyridine‐2‐carboxylate (1) and involved successive deamination, hydrolysis, and decarboxylation. The second method began with 5‐nitrofuro[2,3‐ b ]‐pyridine‐2‐carboxylic acid (V) and consisted of successive decarboxylation, reduction, and deamination reactions.