Synthesis of 1,6‐dihydro‐5‐hydroxy‐6‐oxo‐3‐(trifluoromethyl)‐4‐pyridazinecarboxylates

Abstract

Abstract The reaction of 2‐(alkylamino)‐3‐(trifluoroacetyl)butenedioates 2a‐b with alkyl and aryl hydrazines in ether provides 1,6‐dihydro‐6‐oxo‐3‐(trifluoromethyl)‐4‐pyridazinecarboxylates as their alkylamine salts 3a‐g . The structures of these products are substantiated using 2D nmr and 15 N nmr techniques.