Chlorotrimethylsilane Mediated Synthesis of 5-(2-Hydroxybenzoyl)pyrimidines from 3-Formylchromones

Abstract

The recyclization of 3-formylchromones with a variety of 1,3-NCNbinucleophiles promoted by chlorotrimethylsilane was investigated.A simple and flexible general procedure for the synthesis of series of 5-(2hydroxybenzoyl)pyrimidines and their heterofused analogues was proposed.A set of pyrimidines was obtained in high preparative yields.