Synthesis of 3-Methylenepyrrolidines by Palladium-catalyzed [3+2] Cycloaddition of Alkylidenecyclopropanes with Imines

Abstract

Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh 3 ) 4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products, pyrrolidine derivatives, in good to excellent yields.