Angewandte Chemie International Edition · 1998 · 288 citations · 0 references
Life SciencesBiochemistryChemistryBiocatalysisCatalysisEnzymologyBiocatalytic OxidationEnzyme CatalysisOxidation ReactionsOxidation-reduction ReactionsRedox CatalysisRedox EnzymesAlcohol OxidationAldehydesCopper-catalyzed OxidationHomogeneous Catalysis MechanismsMetal-catalyzed OxidationMetalloenzyme MechanismsOxidative CouplingOxidative Coupling Reactions
Two reaction pathways are catalyzed by the dinuclear copper(II)–phenoxyl complex 1—a functional model for the metalloenzyme galactose oxidase—by the oxidation of primary and secondary alcohols with dioxygen (air) in homogeneous solution to their corresponding aldehydes or ketones and/or 1,2-glycols (oxidative C–C coupling). The reduction product formed is H2O2, not water.