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Synthesis and antibacterial activities of some 4,5-dihydro-1H-1,2,4-triazol-5-ones.
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1997
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1-Ethyl-3,4-disubstituted-4,5-dihydro- 1H-1,2,4-triazol-5-onesMedicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryDerivativesNatural Sciences4,5-Dihydro-1h-1,2,4-triazol-5-one RingOrganic ChemistryAntibacterial AgentAntimicrobial CompoundHeterocycle ChemistryAntibacterial ActivitiesPharmacologyPharmaceutical Chemistry
Twenty-one new 1-methyl- and 1-ethyl-3,4-disubstituted-4,5-dihydro- 1H-1,2,4-triazol-5-ones were synthesized and characterised by elemental analysis, 1H-NMR and IR spectra. These new and 16 recently reported derivatives of 4,5-dihydro-1H-1,2,4-triazol-5-one ring were screened for their antibacterial activities.