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An Expedient Synthesis of Diethyl 1-Azidoalkylphosphonates via the Mitsunobu Reaction
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1992
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Bioorganic ChemistryMitsunobu ReactionBiochemistryNatural SciencesDiversity-oriented SynthesisDiethyl 1-AzidoalkylphosphonatesOrganic ChemistryHigh YieldChemistryNatural Product SynthesisSynthetic ChemistryEnantioselective Synthesis
Diethyl 1-azidoalkylphosphonates were obtained in high yield, and under mild conditions by the reaction of diethyl 1-hydroxyalkyl-phosphonates with hydrazoic acid in the presence of triphenylphosphine/diethyl azodicarboxylate (the Mitsunobu reaction).