Concepedia

Enamines from Terminal Epoxides and Hindered Lithium Amides

David M. Hodgson, Christopher D. Bray, Nicholas D. Kindon

Journal of the American Chemical Society · 2004 · 56 citations · 7 references

DOI

Concepts

Abstract

A new reactivity mode of lithium amides with epoxides leads to hindered enamines. The reaction of some of these enamines with unactivated primary and secondary alkyl halides is described, which expands the range of electrophiles that one can use in the synthesis of mono-alkylated aldehydes.

References

7

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